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Phenotypes Associated with This Genotype
Genotype
MGI:3813539
Allelic
Composition
Men1tm2.1Gfk/Men1+
Genetic
Background
involves: 129T2/SvEms * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm2.1Gfk mutation (1 available); any Men1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• similar in pathology to Men1tm1.1Gfk heterozygotes
• similar in pathology to Men1tm1.1Gfk heterozygotes

neoplasm
• similar in pathology to Men1tm1.1Gfk heterozygotes
• pancreatic adenomas are seen in 71% of mice at or above 540 days of age adrenal cortical adenomas
• rates of pathologies are not significantly different from those of Men1tm1.1Gfk heterozygotes
• predominant type of pancreatic adenoma
• seen in 12.5% of mice at or above 540 days of age
• anterior pituitary microadenoma or adenoma
• similar in pathology to Men1tm1.1Gfk heterozygotes

endocrine/exocrine glands
• gross pituitary abnormalities similar in pathology to those of Men1tm1.1Gfk heterozygotes
• hyperplastic or neoplastic changes are seen more frequently than in controls
• similar in pathology to Men1tm1.1Gfk heterozygotes
• pancreatic adenomas are seen in 71% of mice at or above 540 days of age adrenal cortical adenomas
• rates of pathologies are not significantly different from those of Men1tm1.1Gfk heterozygotes
• predominant type of pancreatic adenoma
• seen in 12.5% of mice at or above 540 days of age
• anterior pituitary microadenoma or adenoma
• similar in pathology to Men1tm1.1Gfk heterozygotes

nervous system
• gross pituitary abnormalities similar in pathology to those of Men1tm1.1Gfk heterozygotes
• anterior pituitary microadenoma or adenoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple endocrine neoplasia type 1 DOID:10017 OMIM:131100
J:116086


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory