Phenotypes Associated with This Genotype

Genotype
MGI:3813502

• Allelic Composition: Tg(Thy1-MAPT*)1Avil/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:182782 )

• 4 month old mutants exhibit a decrease in the volume of the ventral dentate gyrus but not of the dorsal dentate gyrus

• mutants exhibit an increase in neuronal cell death in both the dorsal and ventral dentate gyrus

• marker analysis indicates a decrease in the number of immature neuronal precursors in both the dorsal and ventral dentate gyrus

abnormal hippocampus granule cell layer ( J:182782 )

• 4 month old mutants exhibit a decrease in the number of mature granule cells in the ventral dentate gyrus but not in the dorsal dentate gyrus

• mutants exhibit a decrease in the number of PH3+ cells in the ventral dentate gyrus, indicating decreased cell proliferation of granule neuron precursors in this region

abnormal innervation ( J:182782 )

• increase in GABAergic innervation in the molecular layer of the dorsal dentate gyrus

abnormal neuron morphology ( J:73872 )

• neurons exhibit a pretangle appearance with filaments of MAPT and increased lysosomal abnormalities

hippocampal neuron degeneration ( J:182782 )

• expression of hyperphosphorylated tau is greater in immature neurons of the ventral dentate gyrus, indicating premature neuronal damage

behavior/neurological

behavioral despair ( J:182782 )

• in the Porsolt test, mutants are immobile longer than wild-type animals and spend less time climbing, indicating despair and possibly depression