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Phenotypes Associated with This Genotype
Genotype
MGI:3812468
Allelic
Composition
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/0
Genetic
Background
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1Paz mutation (2 available); any Hba mutation (12 available)
Hbbtm1Tow mutation (1 available); any Hbb mutation (25 available)
Tg(HBA-HBBs)41Paz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation
• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity
• mice exhibit priapism that is associated with elevated levels of adenosine
• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity

Mouse Models of Human Disease
OMIM ID Ref(s)
Priapism, Familial Idiopathic 176620 J:135978


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory