Phenotypes for Hba Hbb Tg(HBA-HBBs)41Paz MGI:3812468 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hba^tm1Paz/Hba^tm1Paz Hbb^tm1Tow/Hbb^tm1Tow Tg(HBA-HBBs)41Paz/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^tm1Paz mutation (2 available); any Hba mutation (10 available)
Hbb^tm1Tow mutation (1 available); any Hbb mutation (47 available)
Tg(HBA-HBBs)41Paz mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal penile erection ( J:135978 )

• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation

• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity

priapism ( J:135978 )

• mice exhibit priapism that is associated with elevated levels of adenosine

• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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