Phenotypes Associated with This Genotype

Genotype
MGI:3812428

• Allelic Composition: Zeb1^tm1Yhi/Zeb1^tm1Yhi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:135179 )

• mice die shortly after birth due to failure to initiate respiration

vision/eye

abnormal iridocorneal angle ( J:135179 )

• iridocorneal adhesions lead to loss of the iridocorneal angle

anterior iris synechia ( J:135179 )

• iridocorneal adhesions are observed in E17.5 embryos

• corneolenticular and iridolenticular adhesions are also evident

abnormal cornea endothelium morphology ( J:135179 )

• E15.5 embryos have higher rates of proliferation of the corneal endothelium

cornea epithelium hypoplasia ( J:135179 )

• corneal epithelium has lower rates of proliferation in E15.5 embryos, though associated keratocytes have higher rates of proliferation

increased cornea thickness ( J:135179 )

• the E17.5 cornea is more than a third thicker than controls

abnormal cornea stroma morphology ( J:135179 )

• stromal keratocyte cells have increased rates of proliferation at E15.5

• there are higher numbers of keratocytes found in the cornea of E17.5 embryos

cornea abrasion ( J:135179 )

• corneolenticular adhesions frequently lead to corneal disruption, with the endothelium being torn away from the cornea and adhering to the lens epithelium