Mouse Genome Informatics
cx
    Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc

involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery
• 100% of mice die within the first 48 hours of birth

cardiovascular system
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

respiratory system
• in mice that die within the first 30 minutes of delivery

homeostasis/metabolism
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cellular
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

Mouse Models of Human Disease
OMIM IDRef(s)
Patent Ductus Arteriosus 607411 J:67208