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Phenotypes Associated with This Genotype
Genotype
MGI:3812381
Allelic
Composition
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Unc mutation (1 available); any Ptgs1 mutation (13 available)
Ptgs2tm1Unc mutation (1 available); any Ptgs2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery
• 100% of mice die within the first 48 hours of birth

cardiovascular system
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

respiratory system
• in mice that die within the first 30 minutes of delivery

homeostasis/metabolism
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cellular
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory