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Phenotypes Associated with This Genotype
Genotype
MGI:3812381
Allelic
Composition
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Unc mutation (1 available); any Ptgs1 mutation (3 available)
Ptgs2tm1Unc mutation (1 available); any Ptgs2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery (J:67208)
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery (J:67208)
• 100% of mice die within the first 48 hours of birth (J:67208)
• 100% of mice die within the first 48 hours of birth (J:67208)

cardiovascular system
• all mice exhibit patent ductus arteriosus (J:67208)
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality (J:67208)
• all mice exhibit patent ductus arteriosus (J:67208)
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality (J:67208)

respiratory system
• in mice that die within the first 30 minutes of delivery (J:67208)
• in mice that die within the first 30 minutes of delivery (J:67208)

homeostasis/metabolism
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery (J:67208)
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery (J:67208)

cellular
• all mice exhibit patent ductus arteriosus (J:67208)
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality (J:67208)
• all mice exhibit patent ductus arteriosus (J:67208)
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality (J:67208)

Mouse Models of Human Disease
OMIM ID Ref(s)
Patent Ductus Arteriosus 607411 J:67208


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory