About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3812381
Allelic
Composition		 Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)
Ptgs2tm1Unc mutation (0 available); any Ptgs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:67208 )
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery
postnatal lethality, complete penetrance ( J:67208 )
• 100% of mice die within the first 48 hours of birth

cardiovascular system
patent ductus arteriosus ( J:67208 )
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

respiratory system
respiratory distress ( J:67208 )
• in mice that die within the first 30 minutes of delivery

homeostasis/metabolism
cyanosis ( J:67208 )
• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cellular
patent ductus arteriosus ( J:67208 )
• all mice exhibit patent ductus arteriosus
• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory