Phenotypes Associated with This Genotype

Genotype
MGI:3812381

• Allelic Composition: Ptgs1^tm1Unc/Ptgs1^tm1Unc; Ptgs2^tm1Unc/Ptgs2^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:67208 )

• 100% of mice die within the first 48 hours of birth

neonatal lethality, incomplete penetrance ( J:67208 )

• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cardiovascular system

patent ductus arteriosus ( J:67208 )

• all mice exhibit patent ductus arteriosus

• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

respiratory system

respiratory distress ( J:67208 )

• in mice that die within the first 30 minutes of delivery

homeostasis/metabolism

cyanosis ( J:67208 )

• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cellular

patent ductus arteriosus ( J:67208 )

• all mice exhibit patent ductus arteriosus

• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality