Phenotypes Associated with This Genotype

Genotype
MGI:3812172

• Allelic Composition: Sirt1^tm1.1Cxd/Sirt1⁺; Trp53^tm1Brd/Trp53⁺
• Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:140089 )

• tumors exhibit extensive aneuploidy and chromosomal aberrations, notably translocations, chromosome breaks, deletions and dicentric chromosomes

increased tumor incidence ( J:140089 )

• mice begin to develop tumors at 5 months of age with tumor incidence reaching 76% by 20 months of age compared to only 2 of 21 Sirt1^tm1.1Cxd heterozygotes and 3 of 23 Trp53^tm1Brd heterozygotes

• however, treatment of mice with resveratrol decreases the incidence of tumors and delays onset

increased lymphoma incidence ( J:140089 )

• 35% of tumors are lymphomas

increased carcinoma incidence ( J:140089 )

• 16% of tumors are carcinomas

increased sarcoma incidence ( J:140089 )

• 46% of tumors are sarcomas

increased teratoma incidence ( J:140089 )

• 22% of tumors are teratomas