Phenotypes for Sirt1 Trp53 MGI:3812167 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sirt1^tm1.1Cxd/Sirt1^tm1.1Cxd Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1^tm1.1Cxd mutation (0 available); any Sirt1 mutation (78 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:140089 )

• some mice die between E16.5 and birth

perinatal lethality, incomplete penetrance ( J:140089 )

• only one mouse survives birth

postnatal lethality, complete penetrance ( J:140089 )

• no mice are alive at weaning

embryonic lethality, incomplete penetrance ( J:140089 )

• fewer than expected mice are alive at E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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