Phenotypes Associated with This Genotype

Genotype
MGI:3812150

• Allelic Composition: Sim1^Rgsc646/Sim1⁺
• Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:133634 )

• mice with this mutation are significantly heavier than normal at 8 and 12 weeks; at 17 weeks, the male founder mouse weighed 57.6 g

hematopoietic system

increased glycosylated hemoglobin level ( J:133634 )

• elevated HbA1c was reported in progeny of the founder mouse at 11 and 16 weeks of age

homeostasis/metabolism

increased glycosylated hemoglobin level ( J:133634 )

• elevated HbA1c was reported in progeny of the founder mouse at 11 and 16 weeks of age

hyperglycemia ( J:133634 )

• at 19 weeks of age, the founder mouse had a serum glucose level of 541.5 mg/dL; hyperglycemia was reported in progeny of the founder mouse at 11 and 16 weeks

increased circulating insulin level ( J:133634 )

• progeny of the founder mouse exhibit hyperinsulinemia

increased urine glucose level ( J:133634 )

• glucosuria was detected in the founder mouse at 19 weeks (score = 4), and in his progeny at 10 and 15 weeks

insulin resistance ( J:133634 )

• progeny of the index mouse exhibit insulin resistance

renal/urinary system

increased urine glucose level ( J:133634 )

• glucosuria was detected in the founder mouse at 19 weeks (score = 4), and in his progeny at 10 and 15 weeks