Phenotypes Associated with This Genotype

Genotype
MGI:3812084

• Allelic Composition: Fbxw8^{Gt(RRT057)Byg}/Fbxw8^{Gt(RRT057)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:130238 )

• while 70% of mice die at birth some survive to weaning

neonatal lethality, incomplete penetrance ( J:130238 )

• 70% of mice die at birth

growth/size/body

decreased embryo size ( J:130238 )

• at E12.5, mice are 83% of wild-type in size

decreased body weight ( J:130238 )

• at 1 month of age, surviving mice are 70% of wild-type weight

slow postnatal weight gain ( J:130238 )

decreased fetal size ( J:130238 )

• at E18.5, mice are 67% of wild-type in size

embryo

decreased embryo size ( J:130238 )

• at E12.5, mice are 83% of wild-type in size

decreased placenta weight ( J:130238 )

• at mid-gestation, placental weight is 60% to 67% of wild-type

respiratory system

atelectasis ( J:130238 )

• following recovery at E18.5, alveolar space is reduced compared to in wild-type mice indicating a failure of lungs to inflate

respiratory distress ( J:130238 )

• recovered E18.5 mice fail to initiate or sustain strong and regular breathing unlike wild-type mice

nervous system

abnormal brain size ( J:130238 )

• despite all other organs being proportionally reduced according to decreased body size, the brain is the same size as in wild-type mice

homeostasis/metabolism

cyanosis ( J:130238 )

• in mice recovered at E18.5

skeleton

skeleton phenotype ( J:130238 )

N • mice exhibit normal vertebral bodies and femurs