Analysis Tools
hearing/vestibular/ear
|
• there are slightly increased numbers of inner hair cells in the middle region of E18.5 embryos
• in the apex region, cochleae had many extra hair cells (nearly two rows of inner hair cells)
|
|
• adult mice exhibit short and disorganized stereocilia bundles
|
|
• some of the outer hair cell bundles are missing in the middle and apical regions
|
|
• nine of 22 mice show shortened or/and malformed cochlea at E18.5
• one ear retained only about one-half turn and another ear retained about three-quarter turn
• majority of the affected ears lost around one-half turn of the cochlea
|
|
• there is a slight but significant reduction in the number of hair cells found in the sacculle of mice (1508 vs. 1705 in wild-type)
|
|
• 2 mice of 22 mice at E18.5 have truncated posterior semicircular canals
|
|
• 2 of 22 mice at E18.5 have truncated ampulla, one posteriorly and one anteriorly
|
|
• 2 mice of 22 mice at E18.5 have truncated anterior semicircular canals
|
|
• 5 of 22 mice at E18.5 have malformed cochlea
|
|
• 4 mice of 22 mice at E18.5 have a truncated endolymphatic duct
|
nervous system
|
• there are slightly increased numbers of inner hair cells in the middle region of E18.5 embryos
• in the apex region, cochleae had many extra hair cells (nearly two rows of inner hair cells)
|
|
• adult mice exhibit short and disorganized stereocilia bundles
|
|
• some of the outer hair cell bundles are missing in the middle and apical regions
|
|
• there is a slight but significant reduction in the number of hair cells found in the sacculle of mice (1508 vs. 1705 in wild-type)
|
