Phenotypes Associated with This Genotype

Genotype
MGI:3812002

• Allelic Composition: Cacng2^stg/Cacng2^stg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced AMPA-mediated synaptic currents ( J:140010 )

• AMPAR mediated miniature excitatory post synaptic currents (mEPSC) in inhibitory nucleus reticularis (nRT) neurons are significantly reduced in frequency and amplitude in P14-17 mice

• amplitude, but not frequency, is decreased in older P21-23 mice although there are fewer events

• AMPAR mediated EPSCs frequency and amplitude are not significantly altered in excitatory relay neurons, with the exception that frequency is decreased in older mice

• ratio of AMPA to NMDA EPSCs is reduced by 50% in nRT neurons

• Purkinje cell climbing and parallel fiber synapses both exhibit a decrease in the ratio of stimulation intensity in AMPA to kainite receptor and mGlur-induced EPSCs(70% and 50% respectively)