Phenotypes Associated with This Genotype

Genotype
MGI:3811915

• Allelic Composition: Myc^tm2.1Atp/Myc^tm2.1Atp; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137630 )

• mice die between E11.25 and E11.75

liver/biliary system

liver hypoplasia ( J:137630 )

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:137630 )

• when embryonic or yolk sac cells are cultured, few abnormal colony-forming unit-granulocyte/macrophage colonies form unlike when wild-type cells are cultured

impaired hematopoiesis ( J:137630 )

• despite normal numbers of hematopoietic stem cells, hematopoiesis is impaired

decreased erythroid progenitor cell number ( J:137630 )

• erythroblast precursors are decreased 1500-fold compared to in wild-type mice due to a 19-fold increased in apoptosis at E9.5 and a 41-fold increased at E10.5

• when embryonic or yolk sac cells are cultured, few abnormal blast-forming unit-erythroid colonies form unlike when wild-type cells are cultured

abnormal proerythroblast morphology ( J:137630 )

• the number of early basophilic erythroblasts is decreased 11.5-fold compared to in wild-type mice

embryo

decreased embryo size ( J:137630 )

• at E11.5

pale yolk sac ( J:137630 )

growth/size/body

decreased embryo size ( J:137630 )

• at E11.5

cardiovascular system

cardiovascular system phenotype ( J:137630 )

N • embryonic vasculature development is normal