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Phenotypes Associated with This Genotype
Genotype
MGI:3811812
Allelic
Composition		 Bmp4tm1Blh/Bmp4+
Gli3Xt-J/Gli3+
Genetic
Background		 involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (23 available)
Gli3Xt-J mutation (3 available); any Gli3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal autopod morphology ( J:42445 )
• apoptotic area in the preaxial mesoderm is completely absent at 12.5 days
• post axial apoptotic areas are normal
polydactyly ( J:42445 )
• 100% with unilateral anterior polydactyly involving the hind limbs only
• defect extends into the metatarsals

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory