Phenotypes Associated with This Genotype

Genotype
MGI:3811792

• Allelic Composition: Tsc1^tm1Djk/Tsc1^tm1Djk; Tg(Camk2a-cre)#Szi/0
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:138621 )

• mice die within the first postnatal week

• however, treatment with rapamycin improves phenotype

behavior/neurological

limb grasping ( J:138621 )

• mice clasp hindlimbs unlike wild-type mice

• however, treatment with rapamycin improves phenotype

decreased locomotor activity ( J:138621 )

• mice are severely hypoactive compared to wild-type mice

• however, treatment with rapamycin improves phenotype

nervous system

increased brain weight ( J:138621 )

• brain weight is 2.5-fold greater than in wild-type mice

• however, treatment with rapamycin improves phenotype

astrocytosis ( J:138621 )

neuron hypertrophy ( J:138621 )