Phenotypes Associated with This Genotype

Genotype
MGI:3811643

• Allelic Composition: Tg(Msx2-nog)14Blh/0
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:140021 )

♀

limbs/digits/tail

abnormal limb morphology ( J:140021 )

pigmentation

abnormal hair shaft melanin granule morphology ( J:140021 )

• melanin production appears reduced

integument

sparse hair ( J:140021 )

• almost no external hairs

abnormal hair shaft morphology ( J:140021 )

• expression analysis indicates severely impaired hair shaft differentiation

abnormal hair shaft melanin granule morphology ( J:140021 )

• melanin production appears reduced

abnormal hair cortex morphology ( J:140021 )

• fail to form a distinct cortex

abnormal hair medulla ( J:140021 )

• fail to form a distinct medulla

abnormal hair follicle morphology ( J:140021 )

• wavy appearance

• deeper portions are often misaligned

• proliferating cells are found throughout the hair bulb including the precortex and hair shaft with fewer proliferating cells located at the base of the follicle

• however, normal numbers of follicles are present

abnormal hair follicle dermal papilla morphology ( J:140021 )

• often appear less compact

absent vibrissae ( J:140021 )

• lack vibrissae

• but vibrissae pads form in the normal pattern