Phenotypes Associated with This Genotype

Genotype
MGI:3811615

• Allelic Composition: Tbx4^tm1.2Pa/Tbx4^tm1.2Pa; Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:117423 )

• following tamoxifen treatment at E6.5, all mice die at E10.5 due to failure of chorioallantoic fusion

embryonic lethality during organogenesis, incomplete penetrance ( J:117423 )

• following tamoxifen treatment at E7.5, 50% of mice die at E10.5 due to failure of chorioallantoic fusion

limbs/digits/tail

limbs/digits/tail phenotype ( J:117423 )

N • despite defects in hindlimb formation following treatment with tamoxifen at E9.5 and E10.5, mice exhibit normal hindlimb identity and forelimb development

N • mice treated with tamoxifen at E11.5 exhibit normal hindlimb morphology

abnormal limb bud morphology ( J:117423 )

• following tamoxifen treatment at E7.5, limb buds form but are degenerating by E11.5 with hindlimb limited outgrowth

abnormal autopod morphology ( J:117423 )

• following tamoxifen treatment at E9.5, the autopod of the hindlimb is thin

• following tamoxifen treatment at E9.5, the space between expression domains of Tbx2 and Tbx3 expression are narrower than in wild type mice and the hindlimb autopod contains fewer cells than in wild-type mice

• however, there is no reduction in cell proliferation rates in the hindlimb autopods of tamoxifen treated mice

abnormal digit morphology ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit abnormal anterior digits of the hindlimb

• following tamoxifen treatment at E10.5, some mice exhibit thin hindlimb digits I and II

fused phalanges ( J:117423 )

• following tamoxifen treatment at E9.5, 33% of mice exhibit fusion of the anterior hindlimb digit; some with parital fusions of digits I and II and others with 4 digits indicating the loss of digit II or fusion of digits I and II

• following tamoxifen treatment at E10.5, 42% of mice exhibit fusion of the anterior hindlimb digits

hindlimb oligodactyly ( J:117423 )

• following tamoxifen treatment at E9.5, 67% of mice exhibit four symmetrical hindlimb digits

• following tamoxifen treatment at E9.5, digits I and II are partially fused in some mice while others have 4 digits indicating the loss of digit II or fusion of digits I and II

absent femur ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis

short femur ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis

short fibula ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit hypoplastic fibulas

short hindlimb ( J:117423 )

• following tamoxifen treatment at E9.5 and E10.5, the hindlimb is shorter than in wild type mice at E14.5

abnormal metatarsal bone morphology ( J:117423 )

• following tamoxifen treatment at E10.5, some mice exhibit a metatarsal of the first digit that originates near the middle of the metatarsal of digit two instead of near the tarsal bone

embryo

abnormal limb bud morphology ( J:117423 )

• following tamoxifen treatment at E7.5, limb buds form but are degenerating by E11.5 with hindlimb limited outgrowth

failure of chorioallantoic fusion ( J:117423 )

• following tamoxifen treatment at E6.5, mice die at E10.5 due to failure of chorioallantoic fusion

• following tamoxifen treatment at E7.5, 50% of mice die at E10.5 due to failure of chorioallantoic fusion

skeleton

fused phalanges ( J:117423 )

• following tamoxifen treatment at E9.5, 33% of mice exhibit fusion of the anterior hindlimb digit; some with parital fusions of digits I and II and others with 4 digits indicating the loss of digit II or fusion of digits I and II

• following tamoxifen treatment at E10.5, 42% of mice exhibit fusion of the anterior hindlimb digits

absent femur ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis

short femur ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit aplastic or severely hypoplastic femurs that do not articulate with the pelvis

short fibula ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit hypoplastic fibulas

abnormal metatarsal bone morphology ( J:117423 )

• following tamoxifen treatment at E10.5, some mice exhibit a metatarsal of the first digit that originates near the middle of the metatarsal of digit two instead of near the tarsal bone

abnormal pelvic girdle bone morphology ( J:117423 )

• following tamoxifen treatment at E9.5 or E10.5, mice exhibit abnormal pelvic connections and hypoplastic pelvises