Phenotypes Associated with This Genotype

Genotype
MGI:3811612

• Allelic Composition: Tbx4^tm1.1Pa/Tbx4^tm1.2Pa; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

fused phalanges ( J:117423 )

• at E15.5, mice exhibit mild or nonexistent anterior digit fusions

brachydactyly ( J:117423 )

• the second digit of the foot is reduced compared to in wild-type mice

fused tarsal bones ( J:117423 )

• mice exhibit a partial fusion of the tarsals

abnormal hindlimb morphology ( J:117423 )

• hindlimbs are turned nearly backwards and do not articulate with the pelvis unlike in wild-type mice

• however, despite reduced hindlimb features apoptosis rates in the hindlimb are normal

short femur ( J:117423 )

• at E15.5, mice exhibit severely hypoplastic femurs that fail to ossify

short fibula ( J:117423 )

• at E15.5, mice exhibit hypoplastic fibulas that fail to ossify

skeleton

fused phalanges ( J:117423 )

• at E15.5, mice exhibit mild or nonexistent anterior digit fusions

fused tarsal bones ( J:117423 )

• mice exhibit a partial fusion of the tarsals

short femur ( J:117423 )

• at E15.5, mice exhibit severely hypoplastic femurs that fail to ossify

short fibula ( J:117423 )

• at E15.5, mice exhibit hypoplastic fibulas that fail to ossify

abnormal pelvic girdle bone morphology ( J:117423 )

• at E15.5, mice exhibit hypoplastic pelvis

• the ischium is fused to the illeum

• neonates exhibit small hips

abnormal ischium morphology ( J:117423 )

• the pelvic rami are absent and the ischium is fused to the illeum

• however, apoptosis rates in the hindlimb are normal