Phenotypes Associated with This Genotype

Genotype
MGI:3811387

• Allelic Composition: Tg(THY1-SNCA*A53T)F53Sud/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:140019 )

• resting tremor initially observed around 8 months of age

hindlimb paralysis ( J:140019 )

• initially observed around 8 months of age

nervous system

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain

motor neuron degeneration ( J:140019 )

• results in hindlimb paralysis around 8 months of age

cellular

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain