Phenotypes for Bmp4 Tg(Sftpc-cre)1Blh MGI:3811315 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bmp4^tm3.1Blh/Bmp4⁺ Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3.1Blh mutation (0 available); any Bmp4 mutation (23 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung morphology ( J:106392 )

• at E16.5 and E18.5, 50% of mice exhibit abnormal lungs with large sacs

abnormal respiratory system physiology ( J:106392 )

• at E16.5, cell proliferation lung epithelium and mesenchyme is decreased 50% compared to in wild-type mice while apoptosis is increased compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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