About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3811282
Allelic
Composition
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Ggt1-cre)M3Egn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm3Jzh mutation (0 available); any Pkd1 mutation (68 available)
Tg(Ggt1-cre)M3Egn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by one month of age from renal failure

renal/urinary system
• increased apoptosis is observed in both cysts and normal looking epithelial tubules of 2 day old mice
• cystic kidneys are first detectable at 10 days of age
• the disease is progressive with cysts dominating the kidney architecture by 26 days of age
• however, glomerular cysts are not observed
• cysts of proximal and distal origin develop at different rates with distal cysts progressively increasing in size until death
• proximal cysts stop growing at 15 days of age and start to regress or completely disappear before death

cellular
• increased apoptosis is observed in both cysts and normal looking epithelial tubules of 2 day old mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:140012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory