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Phenotypes Associated with This Genotype
Genotype
MGI:3811282
Allelic
Composition
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Ggt1-cre)M3Egn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm3Jzh mutation (0 available); any Pkd1 mutation (153 available)
Tg(Ggt1-cre)M3Egn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by one month of age from renal failure

renal/urinary system
• increased apoptosis is observed in both cysts and normal looking epithelial tubules of 2 day old mice
• cystic kidneys are first detectable at 10 days of age
• the disease is progressive with cysts dominating the kidney architecture by 26 days of age
• however, glomerular cysts are not observed
• cysts of proximal and distal origin develop at different rates with distal cysts progressively increasing in size until death
• proximal cysts stop growing at 15 days of age and start to regress or completely disappear before death

cellular
• increased apoptosis is observed in both cysts and normal looking epithelial tubules of 2 day old mice

growth/size/body
• cystic kidneys are first detectable at 10 days of age
• the disease is progressive with cysts dominating the kidney architecture by 26 days of age
• however, glomerular cysts are not observed
• cysts of proximal and distal origin develop at different rates with distal cysts progressively increasing in size until death
• proximal cysts stop growing at 15 days of age and start to regress or completely disappear before death

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:140012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory