Phenotypes Associated with This Genotype

Genotype
MGI:3811093

• Allelic Composition: Syne2^tm1Ngl/Syne2^tm1Ngl
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:139778 )

• dermal fibroblasts display abnormal nuclear envelope architecture and composition

decreased fibroblast cell migration ( J:139778 )

• in a wound healing assay, fibroblasts migrate slower than wild-type cells and exhibit delayed Golgi apparatus re-orientation

integument

abnormal keratinocyte morphology ( J:139778 )

• keratinocytes exhibit abnormal nucleus morphology and size compared to wild-type keratinocytes

thick epidermis ( J:139778 )

• interfollicular epidermal thickness is 25 microns more than in wild-type mice

• however, the mitotic index of epidermal cells is normal