Phenotypes Associated with This Genotype

Genotype
MGI:3811014

• Allelic Composition: Ptk2b^tm1Okig/Ptk2b^tm1Okig
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:139849 )

• VEGF mediated increase in calcium ion mobilization in the cytoplasm of endothelial cells is inhibited

• ATP mediated calcium ion mobilization is normal

cardiovascular system

abnormal physiological neovascularization ( J:139849 )

• no significant increase in the number of blood vessels in the area of injury after hind limb ischemia whereas controls display a noticeable increase

abnormal vascular endothelial cell migration ( J:139849 )

• reduced endothelial precursor cell mobilization

decreased vasodilation ( J:139849 )

• acetylcholine induced relaxation of norepinephrine constricted aorta is weakened

• blood flow recovery after hind limb ischemia is much lower after 3 weeks

muscle

decreased vasodilation ( J:139849 )

• acetylcholine induced relaxation of norepinephrine constricted aorta is weakened

• blood flow recovery after hind limb ischemia is much lower after 3 weeks

cellular

abnormal vascular endothelial cell migration ( J:139849 )

• reduced endothelial precursor cell mobilization