Phenotypes Associated with This Genotype

Genotype
MGI:3811007

• Allelic Composition: Ltb4r1^tm1Adl/Ltb4r1^tm1Adl
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

impaired eosinophil recruitment ( J:63873 )

• after 48 hours, eosinophil recruitment in thioglycollate-induced peritonitis is 33% of wild-type

abnormal neutrophil physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal macrophage physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

cellular

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

impaired eosinophil recruitment ( J:63873 )

• after 48 hours, eosinophil recruitment in thioglycollate-induced peritonitis is 33% of wild-type

abnormal neutrophil physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal macrophage physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal