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Phenotypes Associated with This Genotype
Genotype
MGI:3810999
Allelic
Composition
Del(14Ltb4r2-Ltb4r1)1Bodd/Del(14Ltb4r2-Ltb4r1)1Bodd
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(14Ltb4r2-Ltb4r1)1Bodd mutation (1 available); any Del(14Ltb4r2-Ltb4r1)1Bodd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal numbers of circulating lymphocytes, monocytes, neutrophils and eosinophils and normal serum levels of IgG and IgM
• in response to Ltb4
• following treatment with collagen to induce arthritis, mice exhibit no evidence of pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II

skeleton
• following treatment with collagen to induce arthritis, mice exhibit no evidence of pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II

cellular
• in response to Ltb4

hematopoietic system
• in response to Ltb4


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory