Phenotypes Associated with This Genotype

Genotype
MGI:3810954

• Allelic Composition: Xpl/Y
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J * English fancy stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

polydactyly ( J:6343 , J:24756 )

♂ • the expression of polydactyly varies from a barely discernible thickened hallux or elongated first toe on one feet to multiple extra toes on both hind feet (J:6343)

♂ • Background Sensitivity: penetrance is 90-95% on this background (J:6343)

♂ • preaxial polydactyly of the hind feet (J:24756)

hemimelia ( J:6343 , J:24756 )

♂ • one or both hind legs may be twisted resulting in abnormal positioning of the feet (J:6343)

♂ • 42% of hemizygous males and 12% of heterozygous females display hemimelia (J:6343)

♂ • tibial hemimelia of one or both hind legs (J:24756)

endocrine/exocrine glands

cryptorchism ( J:6343 )

♂ • in all males, causing infertility

renal/urinary system

kidney cyst ( J:6343 )

♂ • observed in some males

hydronephrosis ( J:6343 )

♂ • observed in some males

absent kidney ( J:6343 )

♂ • observed in some males

hydroureter ( J:6343 )

♂ • observed in some males

reproductive system

cryptorchism ( J:6343 )

♂ • in all males, causing infertility

male infertility ( J:6343 )

♂

growth/size/body

kidney cyst ( J:6343 )

♂ • observed in some males