Phenotypes Associated with This Genotype

Genotype
MGI:3810950

• Allelic Composition: Hoxa11^tm1Ssp/Hoxa11^tm1Ssp; Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:71402 )

• only 0.72% of mice survive to P30

premature death ( J:71402 )

• only 0.72% of mice survive to P30

neonatal lethality, incomplete penetrance ( J:71402 )

• some mice die shortly after birth

postnatal lethality, incomplete penetrance ( J:71402 )

• most mice die prior to P30

limbs/digits/tail

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• the calcaneus bone is reduced and fused to the fibula unlike in wild-type mice

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

renal/urinary system

kidney cyst ( J:71402 )

kidney medulla hypoplasia ( J:71402 )

• the medulla layer is smaller and more disorganized than in wild-type mice

abnormal renal tubule morphology ( J:71402 )

• proximal tubule lumens are less distinct than in wild-type mice

• many proximal tubules are occluded

dilated renal tubule ( J:71402 )

• distal tubules are severely dilated

skeleton

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• the calcaneus bone is reduced and fused to the fibula unlike in wild-type mice

growth/size/body

kidney cyst ( J:71402 )