Phenotypes Associated with This Genotype

Genotype
MGI:3810949

• Allelic Composition: Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp}; Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd) or (involves: 129S1/Sv * 129S2/SvPas * 129S7/SvEvBrd * 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:71402 )

• some mice die prior to P30

premature death ( J:71402 )

• some mice die prior to P30

postnatal lethality, incomplete penetrance ( J:71402 )

• some mice die prior to P30

limbs/digits/tail

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• all mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

renal/urinary system

abnormal kidney morphology ( J:71402 )

• mice exhibit an indentation in the anterior region of the left kidney unlike in wild-type mice

kidney cyst ( J:71402 )

• one pair in eight pairs of kidneys exhibit small cysts

kidney medulla hypoplasia ( J:71402 )

• the medulla layer is smaller and more disorganized than in wild-type mice

abnormal renal tubule morphology ( J:71402 )

• proximal tubule lumens are more distinct than in Hoxa11^tm1Ssp Hoxd11^tm1Mrc homozygotes

dilated renal tubule ( J:71402 )

• mice exhibit fewer dilated tubules than in Hoxa11^tm1Ssp Hoxd11^tm1Mrc homozygotes

skeleton

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• all mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

reproductive system

female infertility ( J:71402 )

♀

growth/size/body

kidney cyst ( J:71402 )

• one pair in eight pairs of kidneys exhibit small cysts