Analysis Tools
mortality/aging
 N |
• at weaning, hemizygous male pups are present at the expected Mendelian number/ratio among progeny of crosses between heterozygous female and hemizygous or wild-type male mice
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reproductive system
|
N |
• male mice hemizygous for this mutation exhibit normal fertility
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hearing/vestibular/ear
|
N |
• hemizygous mutant male mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking
• the ABR thresholds of hemizygous mutant males do not differ significantly from those of control heterozygous and wild-type female mice, averaging 29 dB vs. 28 dB and 29 dB, respectively
• fixed, paint-filled inner ear structures of E15.5 hemizygous male embryos exhibit no gross morphological abnormalities
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behavior/neurological
|
N |
• hemizygous mutant male mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking
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