mortality/aging
N |
• mice survive to approximately 14 months
|
behavior/neurological
• resting tremors are detected in mice at about 10 months of age, resulting from motor neuron loss
|
• onset of hindlimb mobility problems is observed around 10 months of age due to motor neuron loss
|
nervous system
N |
• no Lewy body-like pathology is observed in transgenic animals
|
• extensive cell death is observed in spinal cord and brain in adult mice
|
• loss of motor neurons with age
|
cellular
• extensive cell death is observed in spinal cord and brain in adult mice
|