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Phenotypes Associated with This Genotype
Genotype
MGI:3810506
Allelic
Composition
Tg(THY1-SNCA*A30P)M30Sud/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(THY1-SNCA*A30P)M30Sud mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive to approximately 14 months

behavior/neurological
• resting tremors are detected in mice at about 10 months of age, resulting from motor neuron loss
• onset of hindlimb mobility problems is observed around 10 months of age due to motor neuron loss

nervous system
N
• no Lewy body-like pathology is observed in transgenic animals
• extensive cell death is observed in spinal cord and brain in adult mice
• loss of motor neurons with age

cellular
• extensive cell death is observed in spinal cord and brain in adult mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory