Phenotypes Associated with This Genotype

Genotype
MGI:3810484

• Allelic Composition: Bin3^tm1Gcp/Bin3^tm1Gcp
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:133313 )

• numerous large vacuoles in the lens cortex by 8 months of age

• loss of F-actin in lens fiber cells

cataract ( J:133313 )

• develop in the lenses of one or both eyes within a few weeks or months of birth

• in all homozygotes by 6 months

neoplasm

increased lymphoma incidence ( J:133313 )

• increased incidence of lymphoma after 1 year of age

• found in 36% of homozygotes by 18 months

• in lung, liver, intestine, spleen, lymph nodes

• mucosa-associated and follicular lymphomas

increased lung adenocarcinoma incidence ( J:133313 )

• greater sensitivity to radiation induced lung adenocarcinoma

increased incidence of tumors by ionizing radiation induction ( J:133313 )

• greater sensitivity to radiation induced lung adenocarcinoma

respiratory system

lung inflammation ( J:133313 )

• increased incidence of congestion and inflammation

increased lung adenocarcinoma incidence ( J:133313 )

• greater sensitivity to radiation induced lung adenocarcinoma

liver/biliary system

liver inflammation ( J:133313 )

• increased incidence of congestion and inflammation

abnormal hepatocyte morphology ( J:133313 )

• in mice treated with diethylnitrosamine

hematopoietic system

enlarged spleen ( J:133313 )

• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine

extramedullary hematopoiesis ( J:133313 )

• in spleen

anemia ( J:133313 )

• myelodysplasic syndrome

immune system

enlarged spleen ( J:133313 )

• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine

liver inflammation ( J:133313 )

• increased incidence of congestion and inflammation

lung inflammation ( J:133313 )

• increased incidence of congestion and inflammation

growth/size/body

enlarged spleen ( J:133313 )

• splenomegaly develops in response to radiation treatment or treatment with diethylnitrosamine