Phenotypes Associated with This Genotype

Genotype
MGI:3810389

• Allelic Composition: Tax1bp1^tm1Ktj/Tax1bp1^tm1Ktj
• Genetic Background: B6.129P2-Tax1bp1^tm1Ktj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:131849 )

• significantly reduced survival by 18 months

growth/size/body

slow postnatal weight gain ( J:131849 )

• fail to thrive after birth

• grow considerably more slowly than controls

cardiovascular system

abnormal heart valve morphology ( J:131849 )

• all mice that die prematurely have grossly hypertrophic cardiac valve leaflets with cellular infiltration and collagen invasion

• dramatically thickened valve leaflets

• not seen in newborns and young mice through 21 days of age

cardiovalvulitis ( J:131849 )

• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves

immune system

cardiovalvulitis ( J:131849 )

• all mice that die prematurely show severe hypertrophic valvulitis with infiltrations of T cells and macrophages in the cardiac valves

abnormal leukocyte physiology ( J:131849 )

abnormal macrophage chemotaxis ( J:131849 )

• involved in skin infiltration

abnormal neutrophil physiology ( J:131849 )

• involved in skin infiltration

abnormal T cell physiology ( J:131849 )

• involved in skin infiltration

abnormal hypersensitivity reaction ( J:131849 )

• hypersensitivity to injected TNF alpha and IL1 beta

increased interleukin-1 beta secretion ( J:131849 )

• elevated in heart tissues

increased interleukin-2 secretion ( J:131849 )

• elevated in heart tissues

increased tumor necrosis factor secretion ( J:131849 )

• elevated in heart tissues

skin inflammation ( J:131849 )

• skin inflammation that is refractory to treatment is prevalent

integument

skin inflammation ( J:131849 )

• skin inflammation that is refractory to treatment is prevalent

cellular

abnormal macrophage chemotaxis ( J:131849 )

• involved in skin infiltration

hematopoietic system

abnormal leukocyte physiology ( J:131849 )

abnormal macrophage chemotaxis ( J:131849 )

• involved in skin infiltration

abnormal neutrophil physiology ( J:131849 )

• involved in skin infiltration

abnormal T cell physiology ( J:131849 )

• involved in skin infiltration