Phenotypes Associated with This Genotype

Genotype
MGI:3810327

• Allelic Composition: Olig1^tm1And/Olig1^tm1And; Olig2^tm1And/Olig2^tm1And
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:76446 )

• though present at E18.5, no live births are observed

nervous system

absent oligodendrocytes ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord

abnormal nervous system development ( J:76446 )

• neuroepithelial cells differentiate into astrocytes instead of oligodendrocytes

decreased oligodendrocyte progenitor number ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord

decreased motor neuron number ( J:76446 )

• at E10.5, most Isl1/2+ Hb9+ motor neurons are lost at all axial levels in the spinal cord

• no projecting axons are observed in the ventral root

• at E13.5, somatic and visceral motor neurons are absent from the spinal cord

• at E16.5, somatic but not visceral motor neurons are absent from the hindbrain

abnormal ventral interneuron 2 morphology ( J:76446 )

• at E10.5 and E13.5, the number of V2 interneurons is increased compared to in wild-type mice and they are expanded ventrally

• however, the numbers and distribution of V1 and V3 interneurons are normal

growth/size/body

decreased fetal size ( J:76446 )

• at E18.5

cellular

decreased oligodendrocyte progenitor number ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord