Phenotypes Associated with This Genotype

Genotype
MGI:3810269

• Allelic Composition: Igh-J^tm1Jkbv/Igh-J^tm1Jkbv; Igkc^tm1Jkbv/Igkc^tm1Jkbv; Tg(IGH@yH2CM)2Amgn/0; Tg(IGK@yK2)J23.1Jkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:139792 )

• mice have 80-100% the number of B cells as wild-type mice

abnormal immunoglobulin level ( J:139792 )

• unimmunized mice produce significant levels of human IgM and IgG2

• IgM levels in sera ranged from 27.3-109.4 micrograms/ml

• IgG2 levels in sera ranged from 37.6-665.3 micrograms/ml

• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences

hematopoietic system

decreased B cell number ( J:139792 )

• mice have 80-100% the number of B cells as wild-type mice

abnormal immunoglobulin level ( J:139792 )

• unimmunized mice produce significant levels of human IgM and IgG2

• IgM levels in sera ranged from 27.3-109.4 micrograms/ml

• IgG2 levels in sera ranged from 37.6-665.3 micrograms/ml

• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences