Phenotypes Associated with This Genotype

Genotype
MGI:3810268

• Allelic Composition: Igh-J^tm1Jkbv/Igh-J^tm1Jkbv; Igkc^tm1Jkbv/Igkc^tm1Jkbv; Tg(IGH@yH2BM)7Amgn/0; Tg(IGK@yK2)J23.1Jkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:139792 )

• mice have 60-80% the number of B cells as wild-type mice

abnormal immunoglobulin level ( J:139792 )

• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences

• unimmunized mice produce significant levels of human IgM and IgG1

• IgM levels in sera ranged from 110-140 micrograms/ml

• IgG1 levels in sera ranged from 172-298 micrograms/ml

hematopoietic system

decreased B cell number ( J:139792 )

• mice have 60-80% the number of B cells as wild-type mice

abnormal immunoglobulin level ( J:139792 )

• unimmunized mice produce significant levels of human IgM and IgG1

• IgM levels in sera ranged from 110-140 micrograms/ml

• IgG1 levels in sera ranged from 172-298 micrograms/ml

• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences