Phenotypes Associated with This Genotype

Genotype
MGI:3810164

• Allelic Composition: Cln8^mnd/Cln8^mnd
• Genetic Background: involves: B6.KB2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:47292 )

• terminal seizures have been seen

gliosis ( J:47292 )

axon degeneration ( J:47292 )

• many profiles of degenerating myelin sheaths and axons are seen in the white matter of the spinal cord

• lesions in the spinal cord are consistent with Wallerian degeneration

• however, no necrotic or apoptotic nuclei are detected in the central nervous system

abnormal myelination ( J:47292 )

• many profiles of degenerating myelin sheaths and axons are seen in the white matter of the spinal cord

• lesions in the spinal cord are consistent with Wallerian degeneration

behavior/neurological

seizures ( J:47292 )

• terminal seizures have been seen

cellular

gliosis ( J:47292 )