Phenotypes Associated with This Genotype

Genotype
MGI:3810060

• Allelic Composition: mt-Co1^m1Jiha
• Genetic Background: involves: C57BL/6J * M. m. domesticus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:132659 )

• mice exhibit increased blood vessel number and diameter in the heart compared to in wild-type mice

abnormal heart morphology ( J:132659 )

• heart tissue exhibits mitochondrial proliferation, reduced mitochondrial matrix density and cristolysis unlike in wild-type mice

abnormal myocardial fiber morphology ( J:132659 )

• however, no evidence of myofiber disarray is observed

• mice exhibit myocyte hypertrophy, myofibrillar lysis, binucleated cells and interstitial fibrosis

myocardial fiber degeneration ( J:132659 )

• myofibrillar lysis

abnormal heart left ventricle morphology ( J:132659 )

• left ventricular wall thickness is increased 5% compared to in wild-type mice

cardiac interstitial fibrosis ( J:132659 )

abnormal heart ventricle pressure ( J:132659 )

• mice exhibit a 23% reduction in left ventricular inner dimension at end-diastole compared to in wild-type mice

cardiomyopathy ( J:132659 )

• all mice develop cardiomyopathy associated with 5% increase in left ventricular wall thickness, a 23% reduction in left ventricular inner dimension at end-diastole, and a 27% increase in rotation in association with a 28% reduction in circumferential strain vectors and a 42% reduction in radial stretch vectors

• however, no evidence of myofiber disarray is observed

heart inflammation ( J:132659 )

• mice exhibit focal inflammation in the heart

homeostasis/metabolism

edema ( J:132659 )

• mice exhibit interstitial edema in the heart

immune system

heart inflammation ( J:132659 )

• mice exhibit focal inflammation in the heart

muscle

abnormal myocardial fiber morphology ( J:132659 )

• mice exhibit myocyte hypertrophy, myofibrillar lysis, binucleated cells and interstitial fibrosis

• however, no evidence of myofiber disarray is observed

myocardial fiber degeneration ( J:132659 )

• myofibrillar lysis

cardiomyopathy ( J:132659 )

• all mice develop cardiomyopathy associated with 5% increase in left ventricular wall thickness, a 23% reduction in left ventricular inner dimension at end-diastole, and a 27% increase in rotation in association with a 28% reduction in circumferential strain vectors and a 42% reduction in radial stretch vectors

• however, no evidence of myofiber disarray is observed

myopathy ( J:132659 )

• mice exhibit mitochondrial myopathy

cellular

cardiac interstitial fibrosis ( J:132659 )