Phenotypes Associated with This Genotype

Genotype
MGI:3809939

• Allelic Composition: Akap5^tm1.1Jsco/Akap5^tm1.1Jsco
• Genetic Background: involves: 129S * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:138972 )

• resistant to seizure after peritoneal injection of pilocarpine

• the brains of these animals had no obvious morphological abnormalities

abnormal AMPA-mediated synaptic currents ( J:138972 )

• agonist dependent downregulation of AMPA channel was more pronounced

reduced long-term depression ( J:138972 )

• induction of LTD by low frequency stimulation was markedly reduced

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:138972 )

• resistant to seizure after peritoneal injection of pilocarpine

• the brains of these animals had no obvious morphological abnormalities

abnormal spatial learning ( J:138972 )

• deficits in spatial memory retention

decreased anxiety-related response ( J:138972 )

impaired coordination ( J:138972 )

• deficits in motor coordination and strength