Phenotypes Associated with This Genotype

Genotype
MGI:3809892

• Allelic Composition: Dlx6^tm1Jlr/Dlx6^tm1Jlr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:139700 )

• mice die within a day of birth due to aerophagia

craniofacial

craniofacial phenotype ( J:139700 )

N • unlike in Dlx6/Dlx5^tm1Tlu homozygotes, the nasal and otic capsule are normal

mandibular condyloid process hypoplasia ( J:139700 )

• the mandibular condylar process is hypoplastic

absent mandibular coronoid process ( J:139700 )

• the dentary lacks the coronoid process

small mandible ( J:139700 )

• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process

abnormal gonial bone morphology ( J:139700 )

• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

hearing/vestibular/ear

abnormal gonial bone morphology ( J:139700 )

• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

decreased tympanic ring size ( J:139700 )

• the ectotympanic of the ear is shortened

skeleton

mandibular condyloid process hypoplasia ( J:139700 )

• the mandibular condylar process is hypoplastic

absent mandibular coronoid process ( J:139700 )

• the dentary lacks the coronoid process

small mandible ( J:139700 )

• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process

abnormal gonial bone morphology ( J:139700 )

• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

digestive/alimentary system

aerophagia ( J:139700 )

• mice die within a day of birth due to aerophagia