Phenotypes Associated with This Genotype

Genotype
MGI:3809844

• Allelic Composition: Txnip^tm1.1Road/Txnip^tm1.1Road
• Genetic Background: B6.Cg-Txnip^tm1.1Road

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:132756 )

N • mice exhibit normal viability

homeostasis/metabolism

increased circulating ketone body level ( J:132756 )

• mice are hyperketonemic

increased circulating lactate level ( J:132756 )

• plasma lactate levels are higher than in wild-type mice

increased circulating triglyceride level ( J:132756 )

• mice are hypertriglyceridemic

abnormal glucose homeostasis ( J:132756 )

• mice exhibit increased glycolysis compared to in wild-type mice

hypoglycemia ( J:132756 )

• when fed a normal diet or a high fat diet, mice exhibit reduced serum glucose levels compared to in similarly treated wild-type mice

abnormal gluconeogenesis ( J:132756 )

• during a hyperinsulinemic-euglycemic slamp study, basal hepatic glucose production is increased compared to in similarly treated wild-type mice

improved glucose tolerance ( J:132756 )

increased insulin sensitivity ( J:132756 )

• mice exhibit increased extrahepatic insulin sensitivity compared to in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:132756 )

• mouse embryonic fibroblasts are resistant to doxorubicin-induced apoptosis unlike wild-type cells

muscle

increased muscle cell glucose uptake ( J:132756 )

• during a hyperinsulinemic-euglycemic slamp study, skeletal muscle glucose uptake is increased compared to in similarly treated wild-type mice

cellular

increased muscle cell glucose uptake ( J:132756 )

• during a hyperinsulinemic-euglycemic slamp study, skeletal muscle glucose uptake is increased compared to in similarly treated wild-type mice

decreased cellular glucose uptake ( J:132756 )

• mouse embryonic fibroblasts exhibit reduced glucose uptake compared to wild-type cells

abnormal cellular respiration ( J:132756 )

• mice exhibit impaired mitochondrial fuel oxidation and increased glycolysis compared to in wild-type mice

• mouse embryonic fibroblasts exhibit reduced mitochondrial oxidation compared to wild-type cells

reproductive system

reproductive system phenotype ( J:132756 )

N • mice exhibit normal reproduction

growth/size/body

growth/size/body region phenotype ( J:132756 )

N • mice exhibit normal growth