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Phenotypes Associated with This Genotype
Genotype
MGI:3809720
Allelic
Composition		 Traddtm1.1Mak/Tradd+
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traddtm1.1Mak mutation (1 available); any Tradd mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased acute inflammation ( J:138824 )
• macrophages produced significantly less TNF when exposed to LPS
• macrophages also produce less TNF in response to the TLR3 agonist poly(I:C)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory