Phenotypes Associated with This Genotype

Genotype
MGI:3809715

• Allelic Composition: Tg(RIP1-Tag)5Dh/0
• Genetic Background: C3.Cg-Rgs5^tm1.1Rgan Tg(RIP1-Tag)5Dh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:136259 )

• mice exhibit premature death due to hypoglycemia

neoplasm

increased insulinoma incidence ( J:136259 )

• mice exhibit tumor growth with tumor burden and premature death due to hypoglycemia unlike in wild-type mice

preneoplasia ( J:136259 )

• mice exhibit early tumorigenesis with comparable numbers of angiogenic islets per mouse as in Rgs5^tm1.1Rgan/Rgs5^tm1.1Rgan Tg(RIP1-Tag)5Dh mice

homeostasis/metabolism

hypoglycemia ( J:136259 )

• mice exhibit premature death due to hypoglycemia

endocrine/exocrine glands

increased insulinoma incidence ( J:136259 )

• mice exhibit tumor growth with tumor burden and premature death due to hypoglycemia unlike in wild-type mice