Phenotypes for Adam10 Tg(Lck-cre)#Zhu MGI:3809608 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Adam10^tm1Zhu/Adam10^tm1.1Zhu Tg(Lck-cre)#Zhu/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1.1Zhu mutation (0 available); any Adam10 mutation (39 available)
Adam10^tm1Zhu mutation (1 available); any Adam10 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

abnormal T cell differentiation ( J:139042 )

• thymocyte development is impaired

decreased double-positive T cell number ( J:139042 )

decreased CD4-positive, alpha-beta T cell number ( J:139042 )

hematopoietic system

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

abnormal T cell differentiation ( J:139042 )

• thymocyte development is impaired

decreased double-positive T cell number ( J:139042 )

decreased CD4-positive, alpha-beta T cell number ( J:139042 )

endocrine/exocrine glands

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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