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Phenotypes Associated with This Genotype
Genotype
MGI:3809483
Allelic
Composition		 Dkc1tm1.1Pjma/Y
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1.1Pjma mutation (0 available); any Dkc1 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA repair ( J:138335 )
• MEFs show an increase in DNA damage foci after treatment with etoposide and more foci are localized to the telomeres

hematopoietic system
hematopoietic system phenotype ( J:138335 )
N
• no signs of bone marrow failure unlike in patients with X-linked dyskeratosis congenita

homeostasis/metabolism
abnormal DNA repair ( J:138335 )
• MEFs show an increase in DNA damage foci after treatment with etoposide and more foci are localized to the telomeres

integument
integument phenotype ( J:138335 )
N
• no signs of nail dystrophy, skin pigmentation problems or other characteristics seen in patients with X-linked dyskeratosis congenita

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory