Phenotypes Associated with This Genotype

Genotype
MGI:3808702

• Allelic Composition: Nfasc^tm1.1Brp/Nfasc^tm1.1Brp; Tg(Nefl-Nfasc)1Brp/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:139185 )

• despite surviving beyond day 6 to 7, mice die by 18 to 19 days after birth

nervous system

nervous system phenotype ( J:139185 )

N • mice exhibit normal paranodal and nodal complex formation in the peripheral and central nervous system and normal localization of sodium channels to the nodes

abnormal axon morphology ( J:139185 )

• interheminodal gaps are increased compared to in wild-type mice

abnormal oligodendrocyte physiology ( J:139185 )

• migration of oligodendrocyte processes is delayed compared to in wild-type mice with increased interheminodal gaps

• however, by P16 interheminodal gaps are normal