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Phenotypes Associated with This Genotype
Genotype
MGI:3808007
Allelic
Composition		 Pth2tm1Vlcg/Pth2tm1Vlcg
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:138142 )
• complete absence of spermatids in testes
• widespread apoptotic cell death in testes
• early stage spermatocytes and spermatogonia persist
small ovary ( J:138142 )
• atretic ovaries
abnormal meiosis ( J:138142 )
• homologous synapsis is incomplete in first prophase
small testis ( J:138142 )
• half normal length at 80-90 days
decreased testis weight ( J:138142 )
• 1/4 normal weight at 70-80 days

endocrine/exocrine glands
small ovary ( J:138142 )
• atretic ovaries
small testis ( J:138142 )
• half normal length at 80-90 days
decreased testis weight ( J:138142 )
• 1/4 normal weight at 70-80 days

cellular
abnormal spermatid morphology ( J:138142 )
• complete absence of spermatids in testes
• widespread apoptotic cell death in testes
• early stage spermatocytes and spermatogonia persist

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory