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Phenotypes Associated with This Genotype
Genotype
MGI:3807960
Allelic
Composition		 Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation
decreased susceptibility to endotoxin shock ( J:136290 )
• mice are completely resistant to septic shock induced by LPS or CpG DNA unlike wild-type which succumb to shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory