Phenotypes Associated with This Genotype

Genotype
MGI:3807781

• Allelic Composition: Tg(Tox)1Kay/?; Tox^tm1.1Kay/Tox^tm1.1Kay
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell number ( J:131287 )

• transgene expression rescues the reduced number of CD4⁺ T cells found in the Tox^tm1.1Kay homozygotes

• the percentage of thymic single positive CD8⁺ T cells are enhanced 5-fold compared to wild-type

• in addition, there is a population of CD8⁺ T cells that are TCR^int/hiCD5^lo/- which are not found in wild-type mice

hematopoietic system

abnormal T cell number ( J:131287 )

• transgene expression rescues the reduced number of CD4⁺ T cells found in the Tox^tm1.1Kay homozygotes

• the percentage of thymic single positive CD8⁺ T cells are enhanced 5-fold compared to wild-type

• in addition, there is a population of CD8⁺ T cells that are TCR^int/hiCD5^lo/- which are not found in wild-type mice