Phenotypes Associated with This Genotype

Genotype
MGI:3807709

• Allelic Composition: Gja1^tm8Kwi/Gja1⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:132032 )

• mutants are born live die during initial 6.5 months after birth

lethality throughout fetal growth and development, incomplete penetrance ( J:132032 )

• 44% lethality occurs between E14.5 and 16.5

cardiovascular system

cardiovascular system phenotype ( J:132032 )

N • mice do not differ significantly from wild-type in left ventricular (lv) muscle mass, lv end-diastolic volume and lv ejection fraction

N • postnatally, mice do not differ significantly from wild-type in left ventricular (lv) muscle mass, lv end-diastolic volume and lv ejection fraction

ventricular tachycardia ( J:132032 )

• cardiac arrythmias are observed are observed after excorporation for ex vivo cardiac functional analyses including spontaneous and sustained ventricular tachycardias

irregular heartbeat ( J:132032 )

• cardiac arrythmias are observed are observed after excorporation for ex vivo cardiac functional analyses including spontaneous and sustained ventricular tachycardias

• in vivo, spontaneous arrhythmic events such as ventricular extra systole (VES) are observed; frequency and severity of such events increase with by hypoxic stimulation

abnormal heart electrocardiography waveform feature ( J:132032 )

• surface and intercardiac ECGs ex vivo show a broadening of the QRS complex and decrease in the R wave in ventricle activity indicating disturbed impulse propagation

prolonged QRS complex duration ( J:132032 )

abnormal R wave ( J:132032 )

• decrease in the R wave

abnormal myocardial fiber physiology ( J:132032 )

• isolated fetal cardiomyocytes show a 1.6-fold higher beating frequency than wild-type cells

muscle

abnormal myocardial fiber physiology ( J:132032 )

• isolated fetal cardiomyocytes show a 1.6-fold higher beating frequency than wild-type cells