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Phenotypes Associated with This Genotype
Genotype
MGI:3807481
Allelic
Composition
Als2tm1Garo/Als2tm1Garo
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Als2tm1Garo mutation (0 available); any Als2 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mild motor deficits detected by an accelerating rotarod test that become prominent at 8 months of age
• performance in an accelerating rotarod test declines until about 12 months of age
• modest decrease in performance in a muscle strength test

nervous system
• at 18 months of age a high number of degenerating axons are found in corticospinal tracts
• the periaxonal space, of myelinated motor axons in the sciatic nerve and CNS corticospinal tract, is frequently dilated
• slight decrease in axon numbers in L5 ventral roots
• at 18 months of age a high number of degenerating axons are found in corticospinal tracts
• transport of tubulin, but not of neurofilaments, is slower compared to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Amyotrophic Lateral Sclerosis 2, Juvenile; ALS2 205100 J:138147


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory