Phenotypes Associated with This Genotype

Genotype
MGI:3807473

• Allelic Composition: Setd7^tm1Frga/Setd7^tm1Frga
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:136558 )

• about half die during embryogenesis, no time of lethality provided

• survivors appear normal at 4 and 12 months of age

cellular

abnormal cell cycle checkpoint function ( J:136558 )

• MEFs fail to arrest in G1 48 h after doxorubicin treatment and instead continue to proliferate

decreased sensitivity to induced cell death ( J:136558 )

• in MEFs 48 h after doxorubicin treatment

immune system

abnormal spleen physiology ( J:136558 )

• spleen cells fail to arrest in G1 48 h after doxorubicin treatment

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:136558 )

• MEFs and spleen cells fail to arrest in G1 48 h after doxorubicin treatment

• an increase in apoptosis is not seen in MEFs 48 h after doxorubicin treatment unlike in controls